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KMID : 1188320200140040459
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Gut and Liver
2020 Volume.14 No. 4 p.459 ~ p.467
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Unmet Psychosocial Needs of Patients Newly Diagnosed with Ulcerative Colitis: Results from the Nationwide Prospective Cohort Study in Korea
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Moon Jung-Rock
Lee Chang-Kyun
Hong Sung-Noh
Im Jong-Pil
Ye Byong-Duk
Cha Jae-Myung
Jung Sung-Ae
Lee Kang-Moon
Park Dong-Il
Jeen Yoon-Tae
Park Young-Sook
Cheon Jae-Hee
Kim Hye-Sung
Seo Bo-Jeong
Kim Young-Doe
Kim Hyo-Jong
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Abstract
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Background/Aims: Limited data are available regarding psychosocial distress at the time of diagnosis of ulcerative colitis (UC). We investigated the psychosocial burden and factors related to poor health-related quality of life (HRQL) among patients newly diagnosed with moderate-to-severe UC who were affiliated with the nationwide prospective cohort study.
Methods: Within the first 4 weeks of UC diagnosis, all patients were assessed using the Hospital Anxiety and Depression Scale (HADS), Work Productivity and Activity Impairment questionnaire, Inflammatory Bowel Disease Questionnaire (IBDQ), and 12-Item Short Form (SF-12) health survey. A multiple linear regression model was used to identify factors associated with HRQL.
Results: Between August 2014 and February 2017, 355 patients completed questionnaires. Significant mood disorders requiring psychological interventions, defined by a HADS score ≥11, were identified in 16.7% (anxiety) and 20.6% (depression) of patients. Patients with severe disease were more likely to have presenteeism, loss of work productivity, and activity loss than those with moderate disease (all p<0.05). Significant mood disorders had the strongest negative relationship with total IBDQ score, which indicates disease-specific HRQL (β coefficient: ?22.1 for depression and ?40.0 for anxiety, p<0.001). The scores of all SF-12 dimensions, which indicate general HRQL, were remarkably decreased in the study population compared indirectly with previously reported scores in the general population. The Mayo score, C-reactive protein level, and white blood cell count showed significant negative associations with the IBDQ score (p<0.05).
Conclusions: Psychosocial screening and timely interventions should be incorporated into the initial care of patients newly diagnosed with UC.
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KEYWORD
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Colitis, ulcerative, Patient reported outcome measures, Quality of life, Anxiety, Depression
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